In a large mixing bowl, combine the ground beef, onion, panko, milk, eggs, mustard, Worcestershire sauce, and meatloaf seasoning.
Mix to just combine. Don’t over mix or it will be tough.
Press into a loaf pan or 8x11 baking dish.
In a small pot, combine the glaze ingredients and cook over medium heat to combine ingredients and dissolve the sugar.
Brush the uncooked meatloaf with half the glaze.
Bake at 400F for 30 minutes.
Remove from the oven and brush with remaining glaze.
Return to the oven and bake for another 25-30 minutes or until the internal temperature reaches 160F.
Remove from the oven and let sit for 2-3 minutes. Slice and serve warm.
Notes
Use a lean meat and some moisture adding ingredients like breadcrumbs.
They make special meatloaf pans with a double layer with an inside pan that rains the fat away. Here is my favorite.
If not, try placing a few slices of toasted bread under the meat while it cooks to soak up the grease.
Poke some holes in the top of the meatloaf before adding the glaze. Then the glaze will drip down into the meat as it cooks.
Rest the meatloaf before slicing so the juices can redistribute and thicken. This will keep it moist and hold it's shape better. Tent with foil as it rests.